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Given the paucity of studies on this matter, we aimed to compare the clinical characteristics, social functioning, and cognition of male and female adolescents with schizophrenia and to analyze possible differences in early course and adherence to treatment during a six-month followup.Male and female subjects, aged 12 to 17 years, were recruited from the Child Psychiatric Hospital in Mexico City.

Exclusion criteria were active medical comorbidities, drug abuse, and pregnancy.This scale was created for the assessment of perceived influences on compliance with antipsychotic treatment.It is composed of 3 Likert-type subscales related to compliance (prevention, influence of others, and medication affinity) and 5 subscales related to noncompliance (denial/dysphoria, logistical problems, rejection of label, family influence, and negative therapeutic alliance) [20].In adolescence, factors such as the increase of hormonal levels and the maturation of the structures and functions involved in the information processing could account for sex differences [10].For example, a greater loss of cerebral gray matter during brain maturation in males or the protective role of the estrogens in females [11] may in turn affect fundamental aspects of the illness.The study was in compliance with the Helsinki declaration and was approved by the Institutional Review Board.

Child and Adolescent Version (MINI KID): the MINI KID was designed as a structured diagnostic interview to assess short-term psychopathology of children and adolescents.It examines the presence of 23 psychiatric disorders at the present time and throughout life according to DSM-IV and ICD-10 criteria [13].This scale evaluates the severity of symptoms through 30 items which are scored on 1 to 7 scale.Finally, the Pearson correlation coefficient was used to find the correlations between ROMI’s items and adherence to treatment. Most of them (84%) were on their first episode of psychosis, their mean PANSS score was 98.6 (±21.5), and their mean global PSP was 35.7 (±13.6).Men had a longer mean duration of illness and a lower frequency of first psychotic episode (Table 1).Intraclass correlation coefficients 0.70 and 80% of agreement were achieved.

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