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Zika, a flavivirus transmitted mainly by mosquitos in the genus Aedes, was discovered in 1947 in Uganda.

The finding on Yap Island that Zika virus can cause an outbreak numbering more than one hundred confirmed and probable cases is striking.In addition, we drew on formal notifications to WHO under the International Health Regulations (IHR 2005), which are archived in the WHO Event Information Site (EIS).EIS contains information about public health events of potential international concern notified to WHO as required by the International Health Regulations.In South America, the first reports of locally transmitted infection came from Brazil in May 2015.In July 2015 Brazil reported an association between Zika virus infection and GBS.An estimated 73% of Yap residents over three years of age were infected with Zika virus.

No deaths, hospitalizations, or neurological complications are reported.

House-to-house surveys among the island’s small population of 11 250 people identify 185 cases of suspected Zika virus disease.

Of these, 49 are confirmed (RNA identified by PCR or a specific neutralizing antibody response to Zika virus in the serum) and 59 are classified as probable (patients with Ig M antibody against Zika virus who had a potentially cross-reactive neutralizing-antibody response).

Seroprevalence studies in Indonesia, Malaysia and Pakistan indicate widespread population exposure.2007: Zika spreads from Africa and Asia to cause the first large outbreak in humans on the Pacific island of Yap, in the Federated States of Micronesia.

Prior to this event, no outbreaks and only 14 cases of human Zika virus disease had been documented worldwide.

Please note: This document is a historical rendering of the Zika virus disease up until 7 February 2016.